Propolis has been used by man since ancient times as multifaceted antimicrobial drug against several types of ailments. It had been, however forgotten in the mean time due to the discovery and effective use of antibiotic drugs. Now a day, the medicinal application of propolis is reviving mainly due to the emergence of pathogenic strains that show resistance to the drugs. Since it is still an unofficial drug in pharmacy, we analyzed the contents of flavonoids of propolis by Methanol Extraction process and acid hydrolysis method. The present study reveals that, Flavonoid compounds of propolies collected from stingless bee colony were responsible for antibacterial activity of propolis. Antibacterial activities, determined with the well diffusion method against six bacterial species. The minimum inhibitory concentrations (MIC) and maximum inhibitory zones were recorded after incubation. The flavonoid compounds of propolis showed remarkable variations against different species of bacteria. This is an attempt made to facilitate “Back to nature”, a trend of using natural products in treating ailments and other bacterial infections in the present day context.

Key words: Flavonoid, propolis, antibacterial, MIC.

 

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